Maturation-associated gene expression profiles during normal human bone marrow erythropoiesis
نویسندگان
چکیده
منابع مشابه
Evaluation of the expression of human CAP18 gene during neutrophil maturation in the bone marrow.
To understand the gene expression of CAP18 (18-kDa cationic antibacterial protein), a member of cathelicidins, we evaluated mRNA and protein expression of CAP18 using human bone marrow cells and mature neutrophils. Northern blot analysis revealed that CAP18 mRNA was expressed more abundantly in bone marrow cells than mature neutrophils, whereas Western blot analysis indicated that CAP18 protein...
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A B S TR A C T A major factor in the anemia of infection, inflammation, and malignancy is a relative failure of the bone marrow to increase erythropoiesis in response to a shortened red cell survival. The possible causes for this diminished marrow response are: (a) a reduced production of erythropoietin, or, (b) impaired bone marrow response to erythropoietin. In this report studies were perfor...
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Erythroid differentiation is accompanied by dramatic alterations in morphology and membrane mechanical properties resulting, in large part, from reorganization of the membrane skeletal protein network. The 80-kD protein 4.1 is an important organizational component of this membrane skeleton. Recently, it has been recognized that multiple structural isoforms of 4.1 are encoded by a single gene vi...
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ژورنال
عنوان ژورنال: Cell Death Discovery
سال: 2019
ISSN: 2058-7716
DOI: 10.1038/s41420-019-0151-0